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School of Biological Sciences
The University of Adelaide
AUSTRALIA 5005

Contact:
Dr David Ellis
Email


Curvularia

The genus Curvularia contains about 80 species, which are mostly soil or plant pathogens. Recent studies have shown that morphological identification does not correlate with molecular identification (Manamgoda et al. 2012; Yanagihara et al. 2010, da Cunha et al. 2013). In particular, clinical isolates morphologically identified as Curvularia lunata, the most frequently reported clinical species (Revankar and Sutton, 2010) were placed in different, unrelated phylogenetic clades (Yanagihara et al. 2010). Other species, such as C. brachyspora, C. clavata, C. geniculata, C. inaequalis, C. pallescens, C. senegalensis, and C. verruculosa, have also been reported in clinical cases (Revankar and Sutton, 2010, da Cunha et al. 2013).

RG-1 organisms.

Morphological Description: Colonies are fast growing, suede-like to downy, brown to blackish brown with a black reverse. Conidia are pale brown, with three or more transverse septa (phragmoconidia) and are formed apically through a pore (poroconidia) in a sympodially elongating geniculate conidiophore similar to Drechslera. Conidia are cylindrical or slightly curved, with one of the central cells often being larger and darker, germination is bipolar and some species may have a prominent hilum.

Key Features: Dematiaceous hyphomycete producing sympodial, pale brown, cylindrical or slightly curved phragmoconidia, with one of the central cells often being larger and darker.

Molecular Identification: GPDH (Manamgoda et al. 2012) and/or ITS (da Cunha et al. 2013, Irinyi et al. 2015).

References: Ellis (1971), McGinnis (1980), Rippon (1988), de Hoog et al. (2000, 2015).

Culture of Curvularia lunata
Culture of Curvularia lunata.

Conidia of Curvularia lunata
Conidia of Curvularia lunata.

 

MIC data is limited.  Antifungal susceptibility testing of individual strains is recommended.

Antifungal
MIC ug/mL
Antifungal
MIC ug/mL
Antifungal
MIC ug/mL
Range
Range
Range
Amphotericin B
0.03-16
Itraconazole
0.03-32
Voriconazole
0.06-1

 

Mycosis: Phaeohyphomycosis

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