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Sarocladium 

Based on a recent molecular phylogenetic study the taxonomy of Acremonium was reviewed and some medically important species have been transferred to Sarocladium; i.e. S. kiliense (formerly A. kiliense) and S. strictum (formerly A. strictum). Although these genera are morphologically similar they are phylogenetically distant. Sarocladium can be morphologically differentiated from Acremonium by its elongated phialides rising solitary on vegetative hyphae or on conidiophores that are sparsely or repeatedly branched, the production of abundant adelophialides and elongated conidia. (Glenn et al. 1996, Summerbell et al. 2011, Giraldo et al. 2015).

Sarocladium strictum

Sarocladium strictum is commonly found in soil and plant debris. Cutaneous, CAPD-related peritonitis and invasive infections in immunosuppressed patients have been reported.

RG-1 organism.

Morphological Description:
Colonies growing rapidly, moist to slimy, pink or orange; reverse remaining colourless or turning pink to orange. Conidiophores simple, occasionally branched. Phialides slender, arising from submerged or slightly fasciculate aerial hyphae, 20-65 × 1.4-2.5 μm. Submerged sporulation frequent from reduced phialides. Conidia grouped in slimy heads, cylindrical or ellipsoidal, 3.3-5.5 × 0.9-1.8 μm, hyaline.

Molecular Identification: 
Summerbell et al. (2011) revised the genus and recommends using D1/D2 sequences for phylogenetic analysis and sequence-based identification.

References: 
Glenn et al. (1996), Summerbell et al. (2011), Giraldo et al. (2015), de Hoog et al. (2015).

Antifungal Susceptibility: Sarocladium striatum limited data (Australian National data); MIC µg/mL.

No <0.03 0.06 0.125 0.25 0.5 1 2 4 8 16 >32
AmB 5 1 2 2
VORI 5 1 1 1 2
POSA 5 1 2 1 1
ITRA 5 1 1 3

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