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Cyberlindnera fabianii 

Synonymy: 
Candida fabianii

Cyberlindnera fabianii is a rare cause of candidaemia.

RG-1 organism. 

Culture: 
Colonies (SDA) white to cream-coloured smooth, glabrous, yeast-like.

Microscopy: 
Spheroidal to ellipsoidal budding blastoconidia, 3.0-6.5 x 2-5.5 µm in size. No pseudohyphae are produced. Asci when present, are spherical, containing one to four spherical, finely roughened ascospores.

India Ink Preparation: 
Negative - no capsules present.

Dalmau Plate Culture: 
Spherical to ovoid budding yeast cells and occasional pseudohyphae produced.

Molecular Identification: 
ITS sequencing recommended.

MALDI-TOF MS: 
Able to accurately identify this species.

Physiological Tests: + Positive, - Negative, v Variable, w Weak, s Slow, nd No Data
Germ Tube - L-Sorbose - L-Arabinose - D-Glucitol +
Fermentation Sucrose + D-Arabinose - 𝝰-M-D-glucoside +
Glucose + Maltose + D-Ribose - D-Gluconate +
Galactose - Cellobiose + L-Rhamnose - DL-Lactate +
Sucrose + Trehalose + D-Glucosamine - myo-Inositol -
Maltose +,s Lactose - NAD-glucosamine - 2KD-Gluconate -
Lactose - Melibiose - Glycerol + D-Glucuronate nd
Trehalose - Raffinose + Erythritol - Nitrate +
Assimilation Melezitose + Ribitol - Urease -
Glucose + Soluble Starch + Galactitol - 0.1% Cyclohgeximide nd
Galactose - D-Xylose + D-Mannitol + Growth at 37C +

Key Features: 
Germ tube negative yeast and sugar assimilation pattern. Molecular identification may be required.

Antifungal Susceptibility: Cyberlindnera fabianii very limited data (Pfaller et al. 2015 and Australian National data); MIC µg/mL.
No <0.03 0.06 0.125 0.25 0.5 1 2 4 8 16 32 >64
AmB 1 1
FLU 1 1
VORI 5 4 1
POSA 5 3 2
ITRA 1 1
MICA 1 3 1
CAS 1 1
5FC 1 1

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Dr David Ellis
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