Mould Identification: A Virtual Self Assessment
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Unknown 64 = Cladophialophora bantiana
|A 55-year-old man presented because of fever and frequent falls. His medical history included long-term corticoid therapy for systemic sclerosis and chronic hepatitis C-related cirrhosis. A cerebral CT-scan showed a 2 cm diameter ring-enhancing lesion in the left posterior arm of the internal capsule compressing the left lateral ventricle. A neuronavigation-guided frameless needle biopsy was performed and histopathology of biopsy material revealed a brain abscess suspected to be caused by a black mold.|
H&E stained section showing characteristic, brown-pigmented, septate hyphal elements. The hyphae may be short to elongate, distorted or swollen, regularly shaped, or any combination of the above.
Colonies are moderately fast growing, olivaceous-grey, suede-like to floccose and grow at temperatures up to 42-43C.
Conidia are formed in long, sparsely branched, flexuous, acropetal chains from undifferentiated conidiophores. Conidia are one-celled (very occasionally two-celled), pale brown, smooth-walled, ellipsoid to oblong-ellipsoid and are 2-3 x 4-7um in size.
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