Skip to content

Mould Identification: A Virtual Self Assessment

Excellent you have really done well.

Please find additional information below

Unknown 64 = Cladophialophora bantiana

Case History
A 55-year-old man presented because of fever and frequent falls. His medical history included long-term corticoid therapy for systemic sclerosis and chronic hepatitis C-related cirrhosis.  A cerebral CT-scan showed a 2 cm diameter ring-enhancing lesion in the left posterior arm of the internal capsule compressing the left lateral ventricle.  A neuronavigation-guided frameless needle biopsy was performed and histopathology of biopsy material revealed a brain abscess suspected to be caused by a black mold.
Histopathology

H&E stained section showing characteristic, brown-pigmented, septate hyphal elements.  The hyphae may be short to elongate, distorted or swollen, regularly shaped, or any combination of the above.


Note: direct microscopy of tissue is necessary to differentiate between chromoblastomycosis and phaeohyphomycosis where the tissue morphology of the causative organism is mycelial.

Culture

Colonies are moderately fast growing, olivaceous-grey, suede-like to floccose and grow at temperatures up to 42-43C.
Microscopy

Conidia are formed in long, sparsely branched, flexuous, acropetal chains from undifferentiated conidiophores. Conidia are one-celled (very occasionally two-celled), pale brown, smooth-walled, ellipsoid to oblong-ellipsoid and are 2-3 x 4-7um in size.
Comment: Cladophialophora bantiana may be distinguished from Cladosporium species by the absence of conidia with distinctly pigmented hila, the absence of characteristic shield cells and by growth at 42C (compared with Cladophialophora carrionii which has a maximum growth temperature of 35-36C). RG-2 organism.

Cladophialophora bantiana has been isolated from soil and is a recognized agent of cerebral phaeohyphomycosis. The fungus is neurotropic and may cause brain abscess in both normal and immunosuppressed patients.

About Cladophialophora Back to Virtual Assessment

What is your identification?

Cladophialophora carrionii
Cladosporium cladosporioides
Cladophialophora bantiana

Sorry, that answer is incorrect. Please try again.
School of Biological Sciences
Address

THE UNIVERSITY OF ADELAIDE
SA 5005 AUSTRALIA

Contact

Dr David Ellis
Email