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Clinical breakpoints (CBPs) and Epidemiological Cut-Off (ECV) values based on MICs or MECs for Candida and Aspergillus species as endorsed by CLSI.3,4 Note that some genotype-specific CLSI ECVs are now available for Cryptococcus species, but require molecular typing for valid use. 4

Current as at 10 April 2018

Abbreviations: ANID, anidulafungin, MICA, micafungin; CASP, caspofungin; VORI, voriconazole; FLUZ, fluconazole; ITRA, itraconazole; POSA, posaconazole; AMB, amphotericin B. * interpretive criteria for echinocandins against Aspergillus spp. are relevant to an MEC endpoint.


Antifungal
Agent


Species
Species-specific interpretive categories for
CLSI 2-fold broth microdilution MICs (mg/L)
< I = SDD = R > WT < NWT >
ANID C. albicans 0.25 0.5 1
C. dubliniensis 0.12 0.25
C. glabrata 0.12 0.25 0.5
C. guilliermondii 2 4 8
C. krusei 0.25 0.5 1
C. lusitaniae 1 2
C. parapsilosis 2 4 8
C. tropicalis 0.25 0.5 1
CASP C. albicans 0.25 0.5 1
C. glabrata 0.12 0.25 0.5
C. guilliermondii 2 4 8
C. krusei 0.25 0.5 1
C. parapsilosis 2 4 8
C. tropicalis 0.25 0.5 1
A. flavus * 0.5 1
A. fumigatus * 0.5 1
A. niger * 0.25 0.5
A. terreus * 0.25 0.5
MICA C. albicans 0.25 0.5 1
C. dubliniensis 0.12 0.25
C. glabrata 0.06 0.12 0.25
C. guilliermondii 2 4 8
C. krusei 0.25 0.5 1
C. lusitaniae 0.5 1
C. parapsilosis 2 4 8
C. tropicalis 0.12 0.5 1
VORI C. albicans 0.12 0.25-0.5 1
C. glabrata 0.25 0.5
C. krusei 0.5 1 2
C. parapsilosis 0.12 0.25-0.5 1
C. tropicalis 0.12 0.25-0.5 1
A. flavus 2 4
A. fumigatus 1 2
A. niger 2 4
A. terreus 2 4
FLUZ C. albicans 2 4 8
C. dubliniensis 0.5 1
C. glabrata < 32 64
C. guilliermondii 8 16
C. lusitaniae 1 2
C. parapsilosis 2 4 8
C. tropicalis 2 4 8
POSA C. albicans 0.06 0.12
C. glabrata 1 2
C. guilliermondii 0.5 1
C. krusei 0.5 1
C. lusitaniae 0.06 0.12
C. parapsilosis 0.25 0.5
C. tropicalis 0.12 0.25
A. flavus 0.5 1
A. niger 2 4
A. terreus  1 2
ITRA C. glabrata 4 8
C. krusei 1 2
C. lusitania 1 2
C. tropicalis 0.5 1
A. flavus 1 2
A. fumigatus 1 2
A. niger 4 8
A. terreus 2 4
AMB C. albicans 2 4
C. glabrata 2 4
C. krusei 2 4
C. parapsilosis 2 4
C. tropicalis 2 4
A. flavus 4 8
A. fumigatus 2 4
A. niger 2 4
A. terreus 4 8
A. versicolor 2 4

Abbreviations: ANID, anidulafungin, MICA, micafungin; CASP, caspofungin; VORI, voriconazole; FLUZ, fluconazole; ITRA, itraconazole; POSA, posaconazole; AMB, amphotericin B. * interpretive criteria for echinocandins against Aspergillus spp. are relevant to an MEC endpoint.

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