Mould Identification: A Virtual Self Assessment
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Unknown 42 = Lichtheimia corymbifera
|A 22-year-old male with relapsed acute myeloid leukaemia developed pyrexia, pleuritic chest pain and haemoptysis during re-induction chemotherapy. A chest CT scan showed widespread consolidation. A lung biopsy showed the presence of fungal elements and the fungus shown below was isolated.|
GMS stained tissue section from a lung showing typical zygomycete hyphae and by chance a sporangium of Lichtheimia corymbifera.
Colonies are fast growing, floccose, white at first becoming pale grey with age, and up to 1.5 cm high.
Sporangiophores are hyaline to faintly pigmented, simple or sometimes branched arising solitary from the stolons, in groups of three, or in whorls of up to seven. Sporangia are small (10-40 um in diameter) and are typically pyriform in shape with a characteristic conical-shaped columella and pronounced apophysis, often with a short projection at the top. Sporangiospores vary from subglobose to oblong-ellipsoidal (3.0-7.0 x 2.5-4.5 um), are hyaline to light grey and are smooth-walled. Temperature: optimum 35-37C; maximum 45C. RG-2 organism.
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